Last edited by Tygorisar
Wednesday, August 12, 2020 | History

4 edition of Superantigens found in the catalog.

Superantigens

Superantigens

molecular basis for their role in human diseases

  • 80 Want to read
  • 10 Currently reading

Published by ASM Press in Washington, DC .
Written in English


Edition Notes

Statementedited by Malak Kotb and John D. Fraser.
Classifications
LC ClassificationsQR
The Physical Object
Paginationxii, 263 p., [16] p. of plates :
Number of Pages263
ID Numbers
Open LibraryOL22765721M
ISBN 109781555814243

superantigen [soo″per-an´tĭ-jen] any of a group of powerful antigens occurring in various bacteria and viruses that bind outside of the normal T cell receptor site and are able to react with multiple T cell receptor molecules, thus activating T cells nonspecifically. Included are staphylococcal enterotoxins and toxins causing toxic shock syndrome.   Superantigens are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. Superantigens are .

Start studying Superantigen study guide #3. Learn vocabulary, terms, and more with flashcards, games, and other study tools.   Biology faculty member Dr. Amanda Brosnahan acted as editor for a volume on the topic of superantigens in the lab protocol series Methods in Molecular Biology, published by Brosnahan, who began teaching at Concordia University, St. Paul in , worked extensively in the area of superantigens during her graduate and post-doctoral research.

Bacterial superantigens (SAgs) are powerful T-cell stimulatory molecules produced primarily by Staphylococcus aureus and Streptococcus pyogenes. Bacterial SAgs possess the unique ability to cross-link major histocompatibility complex (MHC) class II molecules and T-cell receptors, which in turn is responsible for their ability to illicit an immune response several orders of magnitude greater Cited by: Book Description. This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology .


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Superantigens Download PDF EPUB FB2

Superantigens. A superantigen is a molecule that is able to elicit T lymphocyte responses by circumventing normal antigen processing and presentation functions. Superantigens are defined by their ability to stimulate a large fraction of T cells via interaction with the TCR Vβ domain (Figure ).

Superantigens are predominantly bacterial in. These antigens are called superantigens (Figure 5). Superantigens book of superantigens include: Staphylococcal enterotoxins (food poisoning), Staphylococcal toxic shock Superantigens book (toxic shock syndrome), Staphylococcal exfoliating toxins (scalded skin syndrome) and Streptococcal pyrogenic exotoxins (shock).

Although the bacterial superantigens are the best. Since the discovery of viral superantigens inimmunologists have made a number of new discoveries.

The discoveries, especially those relating to the interplay Superantigens book the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral : Hardcover. Superantigens (Current Topics in Microbiology & Immunology) 1st Edition by B.

Fleischer (Author), H. Sjorgen (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. Format: Hardcover.

John R. Rodgers, Robert R. Rich, in Clinical Immunology (Fourth Edition), Superantigens “ Superantigens ” are microbial proteins that bind both class II MHC molecules and TCR, causing activation of the T cell.

Superantigens include certain bacterial toxins, such as staphylococcal enterotoxin A (SEA) and toxic shock syndrome toxin (TSST), and viral proteins such as the mouse mammary. Superantigens, on the other hand, bind directly to the outside of MHC-II molecules and the TCRs and activate many T4-lymphocytes.

A specific TCR is not required for activation. Production of high levels of IL-2 can result in circulation of IL-2 in the blood leading to symptoms such as fever, nausea, vomiting, diarrhea, and malaise. Superantigens is the first comprehensive examination of these fascinating proteins ever published.

Organized into five sections and sixteen chapters, this volume provides an essential overview of many aspects of superantigen biology. A team of internationally respected researchers covers the basic molecular mechanisms of superantigen action, their structure and function, and their role in.

activation of B cell by SAgs. (3) Superantigens may activate resting T cells that recognize autoantigens and may remain in active state in the presence of autoantigen. Superantigens increase the expression of glucocorticoid receptor β and are associated with decreased corticosteroid response.[16] Other effects:[5,10] Stimulates lymphocyte.

Since the discovery of viral superantigens inimmunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens.

The LibreTexts libraries are Powered by MindTouch ® and are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the California State University Affordable Learning Solutions Program, and Merlot.

We also acknowledge previous National Science Foundation support under grant numbers. The book is organized into 5 sections with a total of 16 chapters.

The first section is an overview of the breadth and scope of superantigen research, including an up-to date catalog of superantigens characterized from both bacteria and viruses, their cellular interactions, and disease associations. SUPERANTIGEN When the immune system encounters a conventional T-dependent antigen, only a small fraction of the T cell population is able to recognize the antigen and become activated.

However, some antigens can polyclonally activate a large fraction of the T cells, setting off massive immune response. These antigens are called superantigens. Viral Superantigens - CRC Press Book Since the discovery of viral superantigens inimmunologists have made a number of new discoveries.

The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that s. Superantigens are a rapidly growing new class of ligands for human B-cells.

The study of their interaction with lymphocytes provides insight into important mechanisms of the immune system. In this book, leading scientists survey the progress recently made in the identification, the nature, the Price: $ COVID Resources.

Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Book Description. Since the discovery of viral superantigens inimmunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens.

This volume combines protocols that encompass the true variety of investigation done on superantigens in the fields of microbiology, immunology, molecular biology, biochemistry, and cellular biology, with a strong focus on disease models utilized to determine the role of superantigens in human.

A comprehensive examination of these fascinating the basic molecular mechanisms of superantigen action, their structure and function, and their role in human diseases.

Explains the clinical consequences of superantigen intoxication and the latest Price: $ Learn superantigens with free interactive flashcards. Choose from 21 different sets of superantigens flashcards on Quizlet. ISBN: OCLC Number: Description: xii, pages: illustrations ; 24 cm.

Contents: Superantigens: structure, function, and diversity / Matthew D. Baker --Expression, purification, and detection of novel streptococcal superantigens / John K. McCormick --Flow cytometric detection of MMTV superantigens / Gary Winslow --Spectrophotometric methods for the.

Superantigens also occur endogen­ ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses.

The list of candidates that are .This volume combines protocols that encompass the true variety of investigation done on superantigens in the fields of microbiology, immunology, molecular biology, biochemistry, and cellular biology, with a strong focus on disease models utilized to determine the role of superantigens in human disease.Superantigens are typically exotoxins secreted by bacteria or endotoxins produced body cells after a viral infection.

Food poisoning is often the result of superantigens as is toxic shock syndrome and scarlet fever. To learn more about the book this website supports, please visit its Information Center.

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